Diabetes / Polysaccharides / Psychics
Influence of alkaline ionized water on spontaneously sufferers of diabetes in GK rats fed with sucrose
Diabetes mellitus: Two ABSTRACTIONS and SINGLE REPORT OF DIABETICS / ALCALICAL WATER TESTING
Jin Man Kim Life Science Division, Research and Development Center, Sunkyong Industries, Kazuhito Yokoyama Public Health Department, Faculty of Medicine, Tokyo University.
The aim of the study was to assess the influence of ionized alkaline water (AIW) on the intensity of diabetic-fed rats receiving sucrose.
One half of the 32 GK rats received AIW and the other half tap water (TW). These two groups were then divided into two subgroups by feeding a 30% sucrose solution with or without sucrose (8 in each group). In the TW group fed with sucrose, blood glucose levels were significantly higher than in the other groups. In comparison with the TW group, the body weight of sucrose administered in both AIW and TW groups increased significantly. In serum with malonodialdehyde (MDA), markers of lipid peroxide, TW group fed with sucrose was significantly higher than AIW and TW groups.
It is suggested that AIW (Alkaline Ionized Water) supplementation may inhibit the increase in blood glucose and lipid peroxide levels in diabetes.
Protective mechanism of reduced water against pancreatic damage by β- lymphocytes: Deterrent effect against reactive oxygen species
Cytotechnology 40: 139-149, 2002. The Netherlands.139
Yuping Li1, Tomohiro Nishimura1, Kiichiro Teruya1, et al , Faculty of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan; 2 Nihon Trim Co. Ltd, 1-8-34 Oyodonaka, Kita-ku, Osaka, Japan: 3 Hita TenryosiCo. Ltd., 647 Nakanoshima, Hita, Oita, Japan; 4 Center of Holistic Medicine and Naturopathy, Schmallenberg-Nordenau, German Correspondence Author; e-mail: sirahata@grt.kyushu-u.ac.jp
abstract
Reactive oxygen species (ROS) cause irreversible damage to biological macromolecules, causing many diseases. Reduced hydrogen (RW) water, such as hydrogen-rich water with reduced electrolytic content and water with natural reduced hydrogen content, such as Hita Tenryosui in Japan and Nordenau in Germany, which are known to improve various diseases, can protect the pancreatic β cell line of the hamster, HIT-T15, from cell damage caused by allergens. Alloxane, a diabetic compound, is used for the induction of type 1 diabetes in animals. Its diabetic effect is exerted by the production of ROS. Alloxane-treated HIT-T15 cells showed decreased viability, increased intracellular ROS, increased cytosole-free Ca2+ concentration, DNA fragmentation, decreased intracellular ATP level and decreased glucose-induced insulin concentration. RW completely prevented the formation of ROS induced by alloxanes, increased cytosol concentration Ca2+, decreased intracellular ATP and glucose stimulated insulin release, and strongly inhibited DNA fragmentation, partially suppressing the decrease in the viability of alloxane-therapeutic cells. The intracellular concentration of ATP and glucose stimulated insulin was increased by RW to 2-3.5 and 2-4 times, respectively, which suggests that RW increases the sensitivity of β cells to glucose and the response of β cells to glucose. The protective activity of RW was stable at 4 ◦C for over a month, but was lost due to autoclaving. These results suggest that RW protects pancreatic β cells from damage to cells caused by alloxanes by preventing the formation of ROS from alloxanes. RW can be useful in the prevention of alloxane-induced type 1 diabetes.